Biochem/physiol Actions

Primary Target5-HT Transporter

Potent and selective serotonin uptake inhibitor (K_i = 5.4 nM); antidepressant

General description

A potent uptake inhibitor highly selective for 5-HT transporter without effect on noradrenalin or dopamine uptake (IC₅₀ = 1.8, 8800 and 41000 nM for 5-HT, noradrenalin and dopamine, respectively). Clinically prescribed as an antidepressant drug. Widely used in research related to depressive disorders.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Garriock, A., et al., 2010. Bio. Psychiatry.67, 133.Gabriel, J.P., et al. 2009. J. Neurosci.29,10387.Torres, G.E., et al. 2003. Nat. Rev. Neurosci.4, 13.

Packaging

25 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful (C)

assay	≥98% (HPLC)
color	white
form	solid
InChI key	WIHMBLDNRMIGDW-UHFFFAOYSA-N
InChI	1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
manufacturer/tradename	Calbiochem^®
potency	1.8 nM IC₅₀
Quality Level	100
SMILES string	Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
solubility	water: 10 mM, ethanol: 50 mM
storage condition	protect from light, OK to freeze
storage temp.	2-8°C

Safety Data Sheet for 5062380001

Cas Number

59729-32-7

This product has met the following criteria to qualify for the following awards:

Citalopram Hydrobromide

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